The Physiome Project Provides
- Databasing of information
- genome, proteome, morphome
- functional behavior of molecules and biological systems
- observations of intact cellular systems, organs, and intact organisms
- Integration and consilience of knowledge
- schema of interactions (descriptive models)
- quantitative descriptions of relationship (casual, statistical, mechanistic)
- computer models of small and large systems
- parameter sets for different cells, tissues, and species
- Network access to databases and models
- platform-independent networked search engines
- platform-independent web operation of models
- access to databases from descriptive and computational models
Welcome to the NSR Physiome Project!
The Physiome Project is the worldwide effort of several loosely connected research groups to define the physiome via databasing and the development of integrated quantitative and descriptive modeling. This work will help determine the future of medicine, change the way we think about human physiology, and strengthen the fabric of international scientific collaboration across political allegiances.
Recent Publications
Cardiac Physiome meeting, November 6-9, 2017, Toronto
NSR, the National Simulation Resource at the University of Washington Department of Bioengineering, provides the following tools in support of the Physiome Project:
The JSim Modeling System
- Home Page (Getting started with JSim)
- Downloads
- JSim Modular Program Constructor (MPC). A tool to assist in building modular JSim MML models.
Physiological Model and Tutorial Repository
- NSR Physiome Models and Information
- Models related to current research (Analyzing the Cardiac Power Grid).
- Tutorials list
- Reproducible modeling and model standards
Collaborative modeling and software efforts
- The Virtual Physiological Rat Project: Understanding the systems biology of cardiovascular disease. UM
- The Cardiac Mechanics Research Group: Investigating the mechanics and electrical dynamics of the normal and diseased heart from molecular to organ scales. UCSD
- Heart and Muscle Mechanics (HAMM) Lab: Researchers in the HAMM Lab use interdisciplinary, multiscale approaches to study contraction in healthy and diseased muscles and develop myofilament-based therapies. UW
- SemGen: SemGen is an experimental software tool for automating the modular composition and decomposition of biosimulation models
- Biological Control Systems, Modeling, and Software: Sauro Lab, Modeling tools for systems and synthetic biologists. UW
University of Washington Bioengineering Courses
- None at this time.
Courses in Physiological Systems Modeling
- No courses currently scheduled.
- Archived course materials are available via the NSR Course Archives.
The Physiome Commission of the International Union of Physiological Sciences, IUPS, provides leadership to the Physiome Project through its satellite and central meetings and through the University of Auckland's IUPS Physiome Website. Please take advantage of the information provided by the IUPS and this website to learn more about the project.
NSR Local User Information (NSR user account holders only)
[This page was last modified 30Apr18, 1:14 pm.]
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.
