MMID4 User Guide


Documentation History

1. MMID4 Overview

1.1. What Is MMID4?
1.2. Vascular Components
1.2.1. Nonexchanging vessels
1.2.2. Exchange units
1.3. Additional Features
1.3.1. Input function generation
1.3.2. Heterogeneity
1.3.3. Parameter tools

2. MMID4 Tutorial

2.1. Getting Started
2.1.1. Overview
2.1.2. The XSIM simulation interface
2.1.3. Setting up a XSIM environment
2.1.4. Running the MMID4 model
2.1.5. Summary
2.2. Basic Exercises
2.2.1. Overview
2.2.2. Generating an input function
2.2.3. Configuring the model
2.2.4. Selecting results for display
2.2.5. Summary
2.3. Basic Indicator Dilution Principles
2.3.1. Overview
2.3.2. Mean transit time
2.3.3. Membrane conductances
2.3.4. The effect of cells on indicator dilution curves
2.3.5. Selecting an appropriate input function
2.3.6. Summary
2.4. Advanced Exercises
2.4.1. Introduction
2.4.2. The effect of tracer consumption
2.4.3. The effect of flow heterogeneity
2.4.4. The influence of nonexchanging vessels
2.4.5. Summary
2.5. Analysis Exercises
2.5.1. Introduction
2.5.2. Parameter optimization
2.5.3. Using deconvolution to generate an input function
2.5.4. Working with noisy data

3. MMID4 Reference

3.1. Overview
3.1.1. Model structure
3.1.2. MMID4, XSIM and the parameters
3.1.3. Using the MMID4 reference
3.2. Input Functions
3.2.1. General
3.2.2. Using reference data curves
3.2.3. Using deconvolution to generate a vascular tracer input curve
3.2.4. Using the function generator to generate a tracer input curve
3.2.5. Scale inputs to the vascular curve
3.2.6. Input function errors and messages
3.3. Heterogeneity
3.3.1. General
3.3.2. Flow Heterogeneity
3.3.3. Heterogeneous membrane conductances and consumption
3.3.4. Heterogeneity errors and messages
3.4. Vascular and BTEX Operators
3.4.1. Introduction
3.4.2. Plasma flow through vascular and BTEX operators
3.4.3. Vascular operators
3.4.4. BTEX operators
3.4.5. Vascular and BTEX operator errors and messages
3.5. Displaying Results
3.5.1. Introduction
3.5.2. Heterogeneity results
3.5.3. Tracer concentrations
3.5.4. Tissue contents (residues)
3.5.5. Residuals
3.5.6. Parameter expressions and scalars
3.5.7. Errors and messages

4. REPORTING BUGS


APPENDIX A. MMID4 TUTORIAL DATABASE CONTENTS


APPENDIX B. PLOTS FROM SELECTED TUTORIAL EXERCISES



Copyright © 1998, National Simulation Resource, University of Washington.
Last modified 11:11am PST, February 27, 1998.