Model: Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocytes.

 

This model is based on the work of A. Michailova and A.D. McCulloch. It has been published in Biophys J. 2001 Aug; 81(2):614-29. It represents an extension of the model by Winslow, et al., Circ. Res. 1999 March 19; 84(5):571-586, found elsewhere at this website under NSR-software-Cellular Models-wrj3. The interface is essentially identical with the exception of an additional button in the lower left hand corner which gives the parameters and fluxes for Michailova and McCulloch's added equations.

1. IMPORTANT !!! To run a demonstration, enter "xhost +" in one of your windows to allow the demonstration program to open windows on your machine !!!

Access to all variables is via clicking the "INPUT" button on the main model page or by selecting "Inputs" under the "Parameters" menu.

2. Diagrams

 

Model Diagram

 

Michailova and McCulloch Extensions

 

 

3. Model demonstrations with parameter sets

The user should inspect the input parameters and the output curves. Output curves can be found under the Results button.

The following parameter sets are can be demonstrated by clicking on them:

3.1. Test parameter set #1.: jbAP.par

Run model. Under: Results" display Plot Area 1.

3.2. Test parameter set #1.: jbAP2.par

Run model. Under: Results" display Plot Area 1.

3.3. Test parameter set #1.: jbAP3.par

Run model. Under: Results" display Plot Area 1.

3.4. Test parameter set #1.: jbAP4.par

Run model. Under: Results" display Plot Area 1.

3.5. Test parameter set #1.: jbAP.noxfr.par

Run model. Under: Results" display Plot Area 1.

3.6. Test parameter set #1.: fjbAP.noxfr2.par

Run model. Under: Results" display Plot Area 1.

 

4. References:

Winslow RL, Rice J, Jafri S, Marban E, O"Rourke B. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ. Res. 1999 Mar 19; 84(5):571-586.

Greenstein JL, WU R, Po S, Tomaselli GF, Winslow RL. Role of the calcium-independent transient outward Current I(to1) in shaping action potential morphology and duration. Circ Res. 2000 Nov 24; 87(11):1026-1033.

Michailova A, and McCulloch A. Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte. Biophys J. 2001 Aug; 81(2):614-29.


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