// This model generated automatically from SBML
// WARNING: Renamed variable source to source_ due to JSim namespace restrictions

// unit definitions
import nsrunit;
unit conversion off;
unit item=scalar;
unit substance = mole;
unit volume = litre;
unit area = metre^2;
unit length = metre;
unit time = second;

// SBML property definitions
property sbmlRole=string;
property sbmlName=string;
property sbmlCompartment=string;

// SBML reactions
// v1: NFkB IKKIkBa => IKKIkBaNFkB 
// v2: IKKIkBaNFkB => NFkB IKK 
// v3: IKKIkBaNFkB => NFkB IKKIkBa 
// v4: IKK IkBa => IKKIkBa 
// v5: IKKIkBa => IKK 
// v6: IKKIkBa => IKK IkBa 
// v7: IKKIkBb NFkB => IKKIkBbNFkB 
// v8: IKKIkBbNFkB => IKK NFkB 
// v9: IKKIkBbNFkB => IKKIkBb NFkB 
// v10: IkBb IKK => IKKIkBb 
// v11: IKKIkBb => IKK 
// v12: IKKIkBb => IKK IkBb 
// v13: NFkB IKKIkBe => IKKIkBeNFkB 
// v14: IKKIkBeNFkB => NFkB IKK 
// v15: IKKIkBeNFkB => NFkB IKKIkBe 
// v16: IkBe IKK => IKKIkBe 
// v17: IKKIkBe => IKK 
// v18: IKKIkBe => IkBe IKK 
// v19: IkBaNFkB IKK => IKKIkBaNFkB 
// v20: IKKIkBaNFkB => IkBaNFkB IKK 
// v21: IkBbNFkB IKK => IKKIkBbNFkB 
// v22: IKKIkBbNFkB => IkBbNFkB IKK 
// v23: IKK IkBeNFkB => IKKIkBeNFkB 
// v24: IKKIkBeNFkB => IKK IkBeNFkB 
// v25: IkBa NFkB => IkBaNFkB 
// v26: 2source => IkBat 2sink 
// v27: IkBaNFkB => IkBa NFkB 
// v28: NFkBn IkBan => IkBanNFkBn 
// v29: IkBanNFkBn => NFkBn IkBan 
// v30: IkBanNFkBn => IkBaNFkB 
// v31: IkBaNFkB => NFkB 
// v32: IkBat => sink 
// v33: IkBan => IkBa 
// v34: IkBa => IkBan 
// v35: source => IkBa sink 
// v36: IkBb NFkB => IkBbNFkB 
// v37: IkBbNFkB => IkBb NFkB 
// v38: IkBbn NFkBn => IkBbnNFkBn 
// v39: IkBbnNFkBn => IkBbn NFkBn 
// v40: IkBbnNFkBn => IkBbNFkB 
// v41: IkBbNFkB => NFkB 
// v42: IkBbt => sink 
// v43: IkBbn => IkBb 
// v44: IkBb => IkBbn 
// v45: source => IkBb sink 
// v46: NFkB IkBe => IkBeNFkB 
// v47: IkBeNFkB => NFkB IkBe 
// v48: NFkBn IkBen => IkBenNFkBn 
// v49: IkBenNFkBn => IkBen NFkBn 
// v50: IkBenNFkBn => IkBeNFkB 
// v51: IkBeNFkB => NFkB 
// v52: IkBet => sink 
// v53: IkBen => IkBe 
// v54: IkBe => IkBen 
// v55: source => IkBe sink 
// v56: NFkBn => NFkB 
// v57: NFkB => NFkBn 
// v58: source => IkBat 
// v59: source => IkBbt 
// v60: source => IkBet 
// v61: IkBa => sink 
// v62: IkBb => sink 
// v63: IkBe => sink 
// v64: IKK => sink 

math main {
  realDomain time second;
  time.min=0;
  extern time.max;
  extern time.delta;

  // variable definitions
  real compartment = 1 volume;
  real k1 = 30;
  real k2 = .03;
  real k3 = 30;
  real k4 = .03;
  real k5 = 30;
  real k6 = .03;
  real k7 = 30;
  real k8 = .03;
  real k9 = 1.221;
  real k10 = 30;
  real k11 = .03;
  real k12 = .45;
  real k13 = 30;
  real k14 = .03;
  real k15 = .66;
  real k16 = .00135;
  real k17 = .00135;
  real k18 = .00135;
  real k19 = 5.4;
  real k20 = .0048;
  real k21 = 30;
  real k22 = .03;
  real k23 = 30;
  real k24 = .03;
  real k25 = 30;
  real k26 = .03;
  real k27 = 9.2137E-5;
  real k28 = 1.0271;
  real k29 = .0168;
  real k30 = 1.0701E-5;
  real k31 = .0168;
  real k32 = 7.644E-6;
  real k33 = .0168;
  real k34 = 1.35;
  real k35 = .075;
  real k36 = .2448;
  real k37 = .00675;
  real k38 = .018;
  real k39 = .012;
  real k40 = .36;
  real k41 = .105;
  real k42 = .2448;
  real k43 = .00675;
  real k44 = .018;
  real k45 = .012;
  real k46 = .54;
  real k47 = .105;
  real k48 = .2448;
  real k49 = .00675;
  real k50 = .018;
  real k51 = .012;
  real k52 = 11.1;
  real k53 = .075;
  real k54 = .82944;
  real k55 = 2.88;
  real k56 = .105;
  real k57 = .41472;
  real k58 = 4.2;
  real k59 = .105;
  real k60 = .41472;
  real k61 = .0072;
  real k62 = .2442;
  real k63 = .09;
  real k64 = .132;
  private real NFkB.amt(time) substance;
  real NFkB(time) substance/volume;
  real NFkB.init substance/volume;
  private real IKKIkBa.amt(time) substance;
  real IKKIkBa(time) substance/volume;
  real IKKIkBa.init substance/volume;
  private real IKKIkBaNFkB.amt(time) substance;
  real IKKIkBaNFkB(time) substance/volume;
  real IKKIkBaNFkB.init substance/volume;
  private real IKK.amt(time) substance;
  real IKK(time) substance/volume;
  real IKK.init substance/volume;
  private real IkBa.amt(time) substance;
  real IkBa(time) substance/volume;
  real IkBa.init substance/volume;
  private real IKKIkBb.amt(time) substance;
  real IKKIkBb(time) substance/volume;
  real IKKIkBb.init substance/volume;
  private real IKKIkBbNFkB.amt(time) substance;
  real IKKIkBbNFkB(time) substance/volume;
  real IKKIkBbNFkB.init substance/volume;
  private real IkBb.amt(time) substance;
  real IkBb(time) substance/volume;
  real IkBb.init substance/volume;
  private real IKKIkBe.amt(time) substance;
  real IKKIkBe(time) substance/volume;
  real IKKIkBe.init substance/volume;
  private real IKKIkBeNFkB.amt(time) substance;
  real IKKIkBeNFkB(time) substance/volume;
  real IKKIkBeNFkB.init substance/volume;
  private real IkBe.amt(time) substance;
  real IkBe(time) substance/volume;
  real IkBe.init substance/volume;
  private real IkBaNFkB.amt(time) substance;
  real IkBaNFkB(time) substance/volume;
  real IkBaNFkB.init substance/volume;
  private real IkBbNFkB.amt(time) substance;
  real IkBbNFkB(time) substance/volume;
  real IkBbNFkB.init substance/volume;
  private real IkBeNFkB.amt(time) substance;
  real IkBeNFkB(time) substance/volume;
  real IkBeNFkB.init substance/volume;
  private real source.amt substance;
  real source_ substance/volume;
  real source_.init substance/volume;
  private real IkBat.amt(time) substance;
  real IkBat(time) substance/volume;
  real IkBat.init substance/volume;
  private real sink.amt substance;
  real sink substance/volume;
  real sink.init substance/volume;
  private real NFkBn.amt(time) substance;
  real NFkBn(time) substance/volume;
  real NFkBn.init substance/volume;
  private real IkBan.amt(time) substance;
  real IkBan(time) substance/volume;
  real IkBan.init substance/volume;
  private real IkBanNFkBn.amt(time) substance;
  real IkBanNFkBn(time) substance/volume;
  real IkBanNFkBn.init substance/volume;
  private real IkBbn.amt(time) substance;
  real IkBbn(time) substance/volume;
  real IkBbn.init substance/volume;
  private real IkBbnNFkBn.amt(time) substance;
  real IkBbnNFkBn(time) substance/volume;
  real IkBbnNFkBn.init substance/volume;
  private real IkBbt.amt(time) substance;
  real IkBbt(time) substance/volume;
  real IkBbt.init substance/volume;
  private real IkBen.amt(time) substance;
  real IkBen(time) substance/volume;
  real IkBen.init substance/volume;
  private real IkBenNFkBn.amt(time) substance;
  real IkBenNFkBn(time) substance/volume;
  real IkBenNFkBn.init substance/volume;
  private real IkBet.amt(time) substance;
  real IkBet(time) substance/volume;
  real IkBet.init substance/volume;
  real v1.rate(time) substance/time;
  real v2.rate(time) substance/time;
  real v3.rate(time) substance/time;
  real v4.rate(time) substance/time;
  real v5.rate(time) substance/time;
  real v6.rate(time) substance/time;
  real v7.rate(time) substance/time;
  real v8.rate(time) substance/time;
  real v9.rate(time) substance/time;
  real v10.rate(time) substance/time;
  real v11.rate(time) substance/time;
  real v12.rate(time) substance/time;
  real v13.rate(time) substance/time;
  real v14.rate(time) substance/time;
  real v15.rate(time) substance/time;
  real v16.rate(time) substance/time;
  real v17.rate(time) substance/time;
  real v18.rate(time) substance/time;
  real v19.rate(time) substance/time;
  real v20.rate(time) substance/time;
  real v21.rate(time) substance/time;
  real v22.rate(time) substance/time;
  real v23.rate(time) substance/time;
  real v24.rate(time) substance/time;
  real v25.rate(time) substance/time;
  real v26.rate(time) substance/time;
  real v27.rate(time) substance/time;
  real v28.rate(time) substance/time;
  real v29.rate(time) substance/time;
  real v30.rate(time) substance/time;
  real v31.rate(time) substance/time;
  real v32.rate(time) substance/time;
  real v33.rate(time) substance/time;
  real v34.rate(time) substance/time;
  real v35.rate(time) substance/time;
  real v36.rate(time) substance/time;
  real v37.rate(time) substance/time;
  real v38.rate(time) substance/time;
  real v39.rate(time) substance/time;
  real v40.rate(time) substance/time;
  real v41.rate(time) substance/time;
  real v42.rate(time) substance/time;
  real v43.rate(time) substance/time;
  real v44.rate(time) substance/time;
  real v45.rate(time) substance/time;
  real v46.rate(time) substance/time;
  real v47.rate(time) substance/time;
  real v48.rate(time) substance/time;
  real v49.rate(time) substance/time;
  real v50.rate(time) substance/time;
  real v51.rate(time) substance/time;
  real v52.rate(time) substance/time;
  real v53.rate(time) substance/time;
  real v54.rate(time) substance/time;
  real v55.rate(time) substance/time;
  real v56.rate(time) substance/time;
  real v57.rate(time) substance/time;
  real v58.rate(time) substance/time;
  real v59.rate(time) substance/time;
  real v60.rate(time) substance/time;
  real v61.rate(time) substance/time;
  real v62.rate(time) substance/time;
  real v63.rate(time) substance/time;
  real v64.rate(time) substance/time;

  // equations
  when (time=time.min) NFkB.amt = NFkB.init*compartment;
  NFkB.amt:time = -1*v1.rate + v2.rate + v3.rate + -1*v7.rate + v8.rate + v9.rate + -1*v13.rate + v14.rate + v15.rate + -1*v25.rate + v27.rate + v31.rate + -1*v36.rate + v37.rate + v41.rate + -1*v46.rate + v47.rate + v51.rate + v56.rate + -1*v57.rate;
  NFkB = NFkB.amt/compartment;
  NFkB.init = 2.5081E-4;
  when (time=time.min) IKKIkBa.amt = IKKIkBa.init*compartment;
  IKKIkBa.amt:time = -1*v1.rate + v3.rate + v4.rate + -1*v5.rate + -1*v6.rate;
  IKKIkBa = IKKIkBa.amt/compartment;
  IKKIkBa.init = 0;
  when (time=time.min) IKKIkBaNFkB.amt = IKKIkBaNFkB.init*compartment;
  IKKIkBaNFkB.amt:time = v1.rate + -1*v2.rate + -1*v3.rate + v19.rate + -1*v20.rate;
  IKKIkBaNFkB = IKKIkBaNFkB.amt/compartment;
  IKKIkBaNFkB.init = 0;
  when (time=time.min) IKK.amt = IKK.init*compartment;
  IKK.amt:time = v2.rate + -1*v4.rate + v5.rate + v6.rate + v8.rate + -1*v10.rate + v11.rate + v12.rate + v14.rate + -1*v16.rate + v17.rate + v18.rate + -1*v19.rate + v20.rate + -1*v21.rate + v22.rate + -1*v23.rate + v24.rate + -1*v64.rate;
  IKK = IKK.amt/compartment;
  IKK.init = .1;
  when (time=time.min) IkBa.amt = IkBa.init*compartment;
  IkBa.amt:time = -1*v4.rate + v6.rate + -1*v25.rate + v27.rate + v33.rate + -1*v34.rate + v35.rate + -1*v61.rate;
  IkBa = IkBa.amt/compartment;
  IkBa.init = .19028;
  when (time=time.min) IKKIkBb.amt = IKKIkBb.init*compartment;
  IKKIkBb.amt:time = -1*v7.rate + v9.rate + v10.rate + -1*v11.rate + -1*v12.rate;
  IKKIkBb = IKKIkBb.amt/compartment;
  IKKIkBb.init = 0;
  when (time=time.min) IKKIkBbNFkB.amt = IKKIkBbNFkB.init*compartment;
  IKKIkBbNFkB.amt:time = v7.rate + -1*v8.rate + -1*v9.rate + v21.rate + -1*v22.rate;
  IKKIkBbNFkB = IKKIkBbNFkB.amt/compartment;
  IKKIkBbNFkB.init = 0;
  when (time=time.min) IkBb.amt = IkBb.init*compartment;
  IkBb.amt:time = -1*v10.rate + v12.rate + -1*v36.rate + v37.rate + v43.rate + -1*v44.rate + v45.rate + -1*v62.rate;
  IkBb = IkBb.amt/compartment;
  IkBb.init = .021428;
  when (time=time.min) IKKIkBe.amt = IKKIkBe.init*compartment;
  IKKIkBe.amt:time = -1*v13.rate + v15.rate + v16.rate + -1*v17.rate + -1*v18.rate;
  IKKIkBe = IKKIkBe.amt/compartment;
  IKKIkBe.init = 0;
  when (time=time.min) IKKIkBeNFkB.amt = IKKIkBeNFkB.init*compartment;
  IKKIkBeNFkB.amt:time = v13.rate + -1*v14.rate + -1*v15.rate + v23.rate + -1*v24.rate;
  IKKIkBeNFkB = IKKIkBeNFkB.amt/compartment;
  IKKIkBeNFkB.init = 0;
  when (time=time.min) IkBe.amt = IkBe.init*compartment;
  IkBe.amt:time = -1*v16.rate + v18.rate + -1*v46.rate + v47.rate + v53.rate + -1*v54.rate + v55.rate + -1*v63.rate;
  IkBe = IkBe.amt/compartment;
  IkBe.init = .015307;
  when (time=time.min) IkBaNFkB.amt = IkBaNFkB.init*compartment;
  IkBaNFkB.amt:time = -1*v19.rate + v20.rate + v25.rate + -1*v27.rate + v30.rate + -1*v31.rate;
  IkBaNFkB = IkBaNFkB.amt/compartment;
  IkBaNFkB.init = .082062;
  when (time=time.min) IkBbNFkB.amt = IkBbNFkB.init*compartment;
  IkBbNFkB.amt:time = -1*v21.rate + v22.rate + v36.rate + -1*v37.rate + v40.rate + -1*v41.rate;
  IkBbNFkB = IkBbNFkB.amt/compartment;
  IkBbNFkB.init = .0090963;
  when (time=time.min) IkBeNFkB.amt = IkBeNFkB.init*compartment;
  IkBeNFkB.amt:time = -1*v23.rate + v24.rate + v46.rate + -1*v47.rate + v50.rate + -1*v51.rate;
  IkBeNFkB = IkBeNFkB.amt/compartment;
  IkBeNFkB.init = .0064977;
  source.amt = source_*compartment;
  source_ = source_.init;
  source_.init = 1;
  when (time=time.min) IkBat.amt = IkBat.init*compartment;
  IkBat.amt:time = v26.rate + -1*v32.rate + v58.rate;
  IkBat = IkBat.amt/compartment;
  IkBat.init = .0054868;
  sink.amt = sink*compartment;
  sink = sink.init;
  sink.init = 0;
  when (time=time.min) NFkBn.amt = NFkBn.init*compartment;
  NFkBn.amt:time = -1*v28.rate + v29.rate + -1*v38.rate + v39.rate + -1*v48.rate + v49.rate + -1*v56.rate + v57.rate;
  NFkBn = NFkBn.amt/compartment;
  NFkBn.init = 2.0366E-4;
  when (time=time.min) IkBan.amt = IkBan.init*compartment;
  IkBan.amt:time = -1*v28.rate + v29.rate + -1*v33.rate + v34.rate;
  IkBan = IkBan.amt/compartment;
  IkBan.init = .19326;
  when (time=time.min) IkBanNFkBn.amt = IkBanNFkBn.init*compartment;
  IkBanNFkBn.amt:time = v28.rate + -1*v29.rate + -1*v30.rate;
  IkBanNFkBn = IkBanNFkBn.amt/compartment;
  IkBanNFkBn.init = .0013739;
  when (time=time.min) IkBbn.amt = IkBbn.init*compartment;
  IkBbn.amt:time = -1*v38.rate + v39.rate + -1*v43.rate + v44.rate;
  IkBbn = IkBbn.amt/compartment;
  IkBbn.init = .021887;
  when (time=time.min) IkBbnNFkBn.amt = IkBbnNFkBn.init*compartment;
  IkBbnNFkBn.amt:time = v38.rate + -1*v39.rate + -1*v40.rate;
  IkBbnNFkBn = IkBbnNFkBn.amt/compartment;
  IkBbnNFkBn.init = 3.0061E-4;
  when (time=time.min) IkBbt.amt = IkBbt.init*compartment;
  IkBbt.amt:time = -1*v42.rate + v59.rate;
  IkBbt = IkBbt.amt/compartment;
  IkBbt.init = 6.3696E-4;
  when (time=time.min) IkBen.amt = IkBen.init*compartment;
  IkBen.amt:time = -1*v48.rate + v49.rate + -1*v53.rate + v54.rate;
  IkBen = IkBen.amt/compartment;
  IkBen.init = .015635;
  when (time=time.min) IkBenNFkBn.amt = IkBenNFkBn.init*compartment;
  IkBenNFkBn.amt:time = v48.rate + -1*v49.rate + -1*v50.rate;
  IkBenNFkBn = IkBenNFkBn.amt/compartment;
  IkBenNFkBn.init = 2.1473E-4;
  when (time=time.min) IkBet.amt = IkBet.init*compartment;
  IkBet.amt:time = -1*v52.rate + v60.rate;
  IkBet = IkBet.amt/compartment;
  IkBet.init = 4.55E-4;
  v1.rate = k7*IKKIkBa*NFkB;
  v2.rate = k9*IKKIkBaNFkB;
  v3.rate = k8*IKKIkBaNFkB;
  v4.rate = k34*IKK*IkBa;
  v5.rate = k62*IKKIkBa;
  v6.rate = k35*IKKIkBa;
  v7.rate = k10*IKKIkBb*NFkB;
  v8.rate = k12*IKKIkBbNFkB;
  v9.rate = k11*IKKIkBbNFkB;
  v10.rate = k40*IKK*IkBb;
  v11.rate = k63*IKKIkBb;
  v12.rate = k41*IKKIkBb;
  v13.rate = k13*IKKIkBe*NFkB;
  v14.rate = k15*IKKIkBeNFkB;
  v15.rate = k14*IKKIkBeNFkB;
  v16.rate = k46*IKK*IkBe;
  v17.rate = k64*IKKIkBe;
  v18.rate = k47*IKKIkBe;
  v19.rate = k52*IKK*IkBaNFkB;
  v20.rate = k53*IKKIkBaNFkB;
  v21.rate = k55*IKK*IkBbNFkB;
  v22.rate = k56*IKKIkBbNFkB;
  v23.rate = k58*IKK*IkBeNFkB;
  v24.rate = k59*IKKIkBeNFkB;
  v25.rate = k1*IkBa*NFkB;
  v26.rate = k28*NFkBn*NFkBn;
  v27.rate = k2*IkBaNFkB;
  v28.rate = k21*IkBan*NFkBn;
  v29.rate = k22*IkBanNFkBn;
  v30.rate = k54*IkBanNFkBn;
  v31.rate = k16*IkBaNFkB;
  v32.rate = k29*IkBat;
  v33.rate = k39*IkBan;
  v34.rate = k38*IkBa;
  v35.rate = k36*IkBat;
  v36.rate = k3*IkBb*NFkB;
  v37.rate = k4*IkBbNFkB;
  v38.rate = k23*IkBbn*NFkBn;
  v39.rate = k24*IkBbnNFkBn;
  v40.rate = k57*IkBbnNFkBn;
  v41.rate = k17*IkBbNFkB;
  v42.rate = k31*IkBbt;
  v43.rate = k45*IkBbn;
  v44.rate = k44*IkBb;
  v45.rate = k42*IkBbt;
  v46.rate = k5*IkBe*NFkB;
  v47.rate = k6*IkBeNFkB;
  v48.rate = k25*IkBen*NFkBn;
  v49.rate = k26*IkBenNFkBn;
  v50.rate = k60*IkBenNFkBn;
  v51.rate = k18*IkBeNFkB;
  v52.rate = k33*IkBet;
  v53.rate = k51*IkBen;
  v54.rate = k50*IkBe;
  v55.rate = k48*IkBet;
  v56.rate = k20*NFkBn;
  v57.rate = k19*NFkB;
  v58.rate = k27*source_;
  v59.rate = k30*source_;
  v60.rate = k32*source_;
  v61.rate = k37*IkBa;
  v62.rate = k43*IkBb;
  v63.rate = k49*IkBe;
  v64.rate = k61*IKK;

  // variable properties
  compartment.sbmlRole="compartment";
  k1.sbmlRole="parameter";
  k2.sbmlRole="parameter";
  k3.sbmlRole="parameter";
  k4.sbmlRole="parameter";
  k5.sbmlRole="parameter";
  k6.sbmlRole="parameter";
  k7.sbmlRole="parameter";
  k8.sbmlRole="parameter";
  k9.sbmlRole="parameter";
  k10.sbmlRole="parameter";
  k11.sbmlRole="parameter";
  k12.sbmlRole="parameter";
  k13.sbmlRole="parameter";
  k14.sbmlRole="parameter";
  k15.sbmlRole="parameter";
  k16.sbmlRole="parameter";
  k17.sbmlRole="parameter";
  k18.sbmlRole="parameter";
  k19.sbmlRole="parameter";
  k20.sbmlRole="parameter";
  k21.sbmlRole="parameter";
  k22.sbmlRole="parameter";
  k23.sbmlRole="parameter";
  k24.sbmlRole="parameter";
  k25.sbmlRole="parameter";
  k26.sbmlRole="parameter";
  k27.sbmlRole="parameter";
  k28.sbmlRole="parameter";
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