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ANT_BISEN

(Matlab) Adenine nucleotide translocator (ANT)

Model number: 0408

Description

 The primary function of Adenine nucleotide translocator (ANT) is to catalyze 
 ADP/ATP exchange across the inner membrane. Under respiring conditions, 
 ATP4− generated by oxidative phosphorylation is exported to the cytosol 
 for use in cellular activities and ADP3− is imported into the mitochondrial 
 matrix for continuous ATP synthesis. Ant is therefore an ADP3−/ATP4− exchanger.

 The two reactions involved in the ANT are:
 1. (cytoplasm) Creatine Kinase (EC 2.7.3.2)
 Phosphocreatine + ADP + H+ <-> Creatine + ATP

 2. (Mito matrix) ATP Hydrolysis (EC 3.6.1.32)
 ATP + H2O <-> ADP + Pi + H+
 Hydrolysis of ATP. 

 Model generated from The Biochemical Simulation Environment (BISEN).


Figure 1: Potential energy across mito membrane.


Figure 2: Progress curves of ATP and ADP in cytoplasm.


Figure 3: Progress curves of ATP and ADP in mito membrane matrix.

Equations

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References

Related Models

Key Terms

TCA, enzyme, BISEN, Cardiac grid, proton, inorganic phosphate, hydrolysis, magnesium, potassium, Gibbs free energy, thermodynamics, Matlab, ANT, creatine, Phosphocreatine, ATP Hydrolysis, Creatine Kinase

Model History

None.

Posted by: BEJ

Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to: staff@physiome.org.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 15Mar18, 10:28 am.]

Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.