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AlphaKetogluterateDehydrogenase_BISEN

Modeling the Alpha-Ketogluterate Dehydrogenase reaction. Translated from BISEN generated Matlab model.

Model number: 0415

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Description

 alpha-Ketogluterate Dehydrogenase (EC 1.2.4.2/EC 2.3.1.61/EC 1.8.1.4):
 
 alpha-Ketogluterate + COAS + NAD + H2O <-> CO2 + SuccinylcoA + NADH + H+

  The fourth reaction in the TCA cycle, final point for CO2 release, and is a
 multi-enzyme complex much like PDH.

 Model generated from The Biochemical Simulation Environment (BISEN).


Figure 1: Progress curves of the substrates. Circles are output from Matlab version.

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References

Related Models

Key Terms

TCA, enzyme, BISEN, Cardiac grid, proton, inorganic phosphate, hydrolysis, magnesium, potassium, Gibbs free energy, thermodynamics, Matlab, SuccinateCoA, Ketogluterate, NAD, CO2, carbon dioxide

Model History

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Posted by: BEJ

Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to: staff@physiome.org.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 15Mar18, 1:47 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.