This page will look better in a graphical browser that supports web standards, but is accessible to any browser or internet device.

Served by Samwise.

Cardiac Physiome Society workshop: November 6-9, 2017 , Toronto

Comp6_Recirc

Six compartment model with flow, exchange, and recirculation.

Model number: 0118

Run Model: 
    Help running a JSim model.
Java runtime required. Web browser must support Java Applets.
(JSim model applet may take 10-20 seconds to load.)

Description

    System is composed of 6 compartments, five of them in series, with one
 in parallel. The system is divided into three operators with recirculation
 as diagrammed.  Exchange is allowed in only the first operator. The second
 and third operators are each composed of two stirred tanks operators in series.
 The input function, Cin, is positioned between the first and second
 operators but could be positioned anywhere. A fractional clearance occurs
 between the output of the third operator with the remainder recirculating
 to the first operator.

   This model can be used to explore the theory of John L.Stephenson,
 Bull Math Biophys 10: 117-121, 1948.and Bull Math Biophys 22:1-17, 1960.



Figure: A plot of concentration as a function of time for each of the compartment outflows, where CC2 is the outflow conentration from the system before recirculating into compartment CA1. Concentrations are in mM.

Diagram:

 
                                        CC2*(1-clear)
            <----------<---------------------------<---------------<---------------<
          Fp|    OPERATOR 1         Cin       OPERATOR 2             OPERATOR 3    |
            |  _________________     |     ______   _______      _______  _______  ^
            v  |Vp     CA1(t)  | CA1 v     |VB1  |  |VB2  |      |VC1  |  |VC2  |  |
    Creturn -->|               |--->(+)--->| CB1 |->| CB2 |----->| CC1 |->| CC2 |->|
               |      PSg      |           |_____|  |_____|      |_____|  |_____|
               |       ^       |
               --------|--------             FLOW = Fp ml/(g*min)  -->
               |       v       |
               |               |
               |Visfp  CA2(t)  |
               -----------------

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Operator A, a single stirred tank with permeation into a nonflowing tank.





Operator B, a pair of tanks in series with inputs from A1 and from Cin:





Operator C, same as B but no other input:





Return to Operator A:



Where Vp is the volume of the plasma space, PSg is the permeability surface area product, Visfp is the ISF volume fraction in 1 gram of tissue, clear is the fractional clearance, VB is the plasma volume fraction in 1 gram of B tissue and VC is the plasma volume fraction in 1 gram of C tissue.

Download JSim model project file

References

 John L.Stephenson, Bull Math Biophys 10: 117-121, 1948.

 John L.Stephenson, Bull Math Biophys 22:1-17, 1960.

Related Models

Single Compartment Models:

Two Compartment Models:

N>2 Compartment Models:

Osmotic Exchange:

Pharmacology:

Key Terms

compartment, compartmental, flow, first order process, recirculating, tutorial, transit time, clearance, six compartment

Model Feedback

We welcome comments and feedback for this model. Please use the button below to send comments:

Model History

Get Model history in CVS.

Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send one reprint to the address given below:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:27 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.