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TwoCompExampMPC

Example JSim model generated from Modular Program Constructor (MPC). Three species (A, B, C), two compartment model with two reactions in compartment two with species concentrations described by ordinary differential equations (ODEs). Taken from 2015 F1000 article.

Model number: 0345

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Description

 This is the example used to reproduce Figure 2 (Solution to two compartment model 
 generated from MPC.) of Jardine et al., 2015 paper describing the MPC software.
 To run simulation go to the 'Run Time' tab and hit the 'Run' button near the top of
 page. 'Figure2' plot page on left should display results as decribed in paper.
 External imput for species 'A' is an Lag Normal input function. There is no flow in
 of species 'B' and 'C'. 
  



Figure: Solution to two compartment model generated from MPC. Species concentrations plotted as a function of time. Species A (red), B (green), C (blue). Compartment 1: solid line, Compartment 2: dashed line. Lag Normal external input for species A is Ain, the black solid line.

Equations

The equations for this model may be viewed by running the JSim model applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

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References

 Jardine B, Raymond G and Bassingthwaighte J. Semi-automated Modular Program Constructor 
 for physiological modeling: Building cell and organ models, 
 [version 1; referees: awaiting peer review] F1000Research 2015, 4:1461 
 (doi: 10.12688/f1000research.7476.1)

 Butterworth E, Jardine BE, Raymond GM, Neal ML, Bassingthwaighte JB. 
 JSim, an open-source modeling system for data analysis, 
 [v3; ref status: indexed, http://f1000r.es/3n0] 
 F1000Research 2014, 2:288 (doi: 10.12688/f1000research.2-288.v3) 

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Key Terms

modular modeling, JSim, computational biology, compartmental modeling, MPC, enzyme reactions, ODE, two compartment

Model History

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Posted by: BEJ

Acknowledgements

Please cite www.physiome.org in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to: staff@physiome.org.
Or send a copy to:
The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

[This page was last modified 02Nov16, 2:43 pm.]

Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.