http://physiome.org/model/ 2008-10-10T11:47:20-07:00 http://physiome.org/model/ http://physiome.org/model/lib/images/favicon.ico text/html 2008-10-06T09:44:20-07:00 Feng Gao http://physiome.org/model/doku.php?id=Tutorials:Lung&rev=1223311460&do=diff Mechanics OneAlvLung One Alveolus Lung Lung_RC Lung modeled analogously as electrical RC circuit OneTank_RC_GasModel with variable pressure source, resistance and compliance with some initial concentration in the tank.TwoTank_HumanRC Airflow from atmosphere to Bronchi to Alveoli modeled with 2 compartments.TwoTank_Gas This model is based on Lutchen et al. A nonlinear model combining pulmonary mechanics and gas concentration dynamics. IEEE Trans. Biomed. Eng. 29: 629-641, 1982.Bronchi_Bronchi… text/html 2008-09-25T13:06:33-07:00 Gary M. Raymond http://physiome.org/model/doku.php?id=Transport_Physiology:Chemical-enzymatic_reactions:Gas_buffers:HbO2CO2H:model_index&rev=1222373193&do=diff HbO2_CO2H: Model for O2 binding to hemoglobin at varied pCO2 and pH. [Illustrative Diagram] Detailed Description Equations Code: the JSim project file. Run Model References Related Models Key Terms: oxygen binding, hemoglobin, dissociation curves, saturation curves, equilibrium dissociation, P50, binding rates, Hill coefficient, apparent cooperativity, pH, Bohr effect, Haldane effect, cooperative binding, multisite binding text/html 2008-09-25T13:04:49-07:00 Gary M. Raymond http://physiome.org/model/doku.php?id=Transport_Physiology:Chemical-enzymatic_reactions:Gas_buffers:HbO2CO2H:model_detail&rev=1222373089&do=diff Go up a level to model_index [Illustrative Diagram] Oxygen binds to all 4 sites of hemoglobin's heme sites, but the affinities are cooperative (meaning that affinity increases for each site filled. Further the affinities are influenced by pH and by the binding of CO2 to the protein's side chains. This model assumes equilibrium binding, i.e. instantaneous binding in accord with the relevant concentration levels. Thus although each reaction might be described by an on and an off reactio… text/html 2008-09-19T15:51:55-07:00 Gary M. Raymond http://physiome.org/model/doku.php?id=Tutorials:jsim_models_webmodel_alveolus_RC&rev=1221864715&do=diff alveolus_RC