Run the model. See output under Results: Plot Area 1. The response of the system when the solute is constrained to just the plasma space, compared to the solute entering the ISF space, with concentrations measured at the outflows of this two-organ "whole-body" model.
Run the model. Tracer concentration-time courses under Results: Plot Area 1 for 4-organ, 3-tissue-region model analogous to that in Figure 9.5 (zero clearance). Each "organ" was composed of regions for plasma, ISF, and cells. An extracellular flow marker enters the former two regions only; tracer water enters all three regions.
Semilog plots of plasma concentrations of markers for plasma, ECF and water spaces when clearance is exactly 30% of the flow or "cardiac output" in the model used in Figure 9.6. All curves have a monoexponential tail.
Semilog plot of plasma concentration time curves for a strictly intravascular marker which is gradually cleared from the circulation. The tails of the curves are fitted by a single exponential. The loss rate or clearance was set at 0, 5, 10, 15, and 20% of the whole body recirculation. Monoexponential curves fitting the "data" from 100 to 200 seconds extrapolate back to an apparent common intersection at negative time. The intercept at t=0 is lower with clearance > 0, and using its value, C(t=0) , gives overestimates of Vpl .
Search the NSR web site.
Copyright © 2000, National Simulation Resource, University of Washington.
Contact firstname.lastname@example.org with comments, questions, or critiques.