This page will look better in a graphical browser that supports web standards, but is accessible to any browser or internet device.

Served by Samwise.

Cardiac Physiome Society workshop: November 6-9, 2017 , Toronto

BTEX20radialDiffusion

A two region model of capillary and cell with cell subdivided into 20 subregions with axial and radial diffusion. Time-dependent plots of contours and center-of-mass of material are calculated using MATLAB.

Model number: 0327

Run Model: 
    Help running a JSim model.

Description

   This is a modification of the BTEX20 model. Radial diffusion
has been included by subdividing the tissue region into 20
layers and solving the 2-D time dependent problem. The model
includes a java interface to Matlab(TM) to make a movie (avi file)
of the concentration contours in the capillary and tissue as
a function of time. In order to use this feature, the user
must have the Matlab(TM) routines and this JSim project file in
the user's directory, along with the Matlab(TM) path set to that
directory. The two lines of code at the end of this model
which call the java interface to Matlab(TM) have been commented out
(see code above). The Matlab routines are contained in a
tar file which can be downloaded from this page along with
the project file.


The following graphs are a snapshot at the end of the model run of contours of the concentration in the capillary and surrounding tissue. Top panel shows the center of Mass of the substance (red tissue only, blue tissue+capillary).
Panel Bottom Left shows the outflow on a log(Time)-linear(Concentration) plot. Panel Bottom Right shows the outflow on a linear(Time)-log(Concentration) plot. Parameters for this run are indicated in the middle of the Bottom Panel.

Equations

The equations for this model may be viewed by running the applet and clicking on the Source tab at the bottom left of JSim's Run Time graphical user interface. The equations are written in JSim's Mathematical Modeling Language (MML). To make the avi Movies, you must have Matlab installed, and the path set to the directory where the JSim project and Matlab files are stored. See the Introduction to MML and the MML Reference Manual. Additional documentation for MML can be found by using the search option at the Physiome home page.

Download matlab files and project in tar archive.

Download FlowLimited.avi Movie

Blue-white curve is the center of mass including the capillary.
Red-white curve is the center of mass excluding the capillary.

References


W.C. Sangren and C.W. Sheppard.  A mathematical derivation of the
exchange of a labelled substance between a liquid flowing in a
vessel and an external compartment.  Bull Math BioPhys, 15, 387-394,
1953.

C.A. Goresky, W.H. Ziegler, and G.G. Bach. Capillary exchange modeling:  
Barrier-limited and flow-limited distribution. Circ Res 27: 739-764, 1970.

J.B. Bassingthwaighte. A concurrent flow model for extraction
during transcapillary passage.  Circ Res 35:483-503, 1974.

B. Guller, T. Yipintsoi, A.L. Orvis, and J.B. Bassingthwaighte. Myocardial 
sodium extraction at varied coronary flows in the dog: Estimation of 
capillary permeability by residue and outflow detection. Circ Res 37: 359-378, 1975.

C.P. Rose, C.A. Goresky, and G.G. Bach.  The capillary and
sarcolemmal barriers in the heart--an exploration of labelled water
permeability.  Circ Res 41: 515, 1977.

J.B. Bassingthwaighte, C.Y. Wang, and I.S. Chan.  Blood-tissue
exchange via transport and transformation by endothelial cells.
Circ. Res. 65:997-1020, 1989.

Poulain CA, Finlayson BA, Bassingthwaighte JB.,Efficient numerical methods 
for nonlinear-facilitated transport and exchange in a blood-tissue exchange 
unit, Ann Biomed Eng. 1997 May-Jun;25(3):547-64. 

Modular Program Constructor (MPC)

  • Download zip file containing MPC files used to generate this model.
  • JSim MPC. More information about the tool used in building this model.
  • Related Models

    Key Terms

    plasma,cell,2-d, radial diffusion, axial diffusion, center of mass, Java interface, Matlab movie, avi, statistics, MPC

    Model Feedback

    We welcome comments and feedback for this model. Please use the button below to send comments:

    Model History

    Get Model history in CVS.

    Posted by: Name

    Acknowledgements

    Please cite www.physiome.org in any publication for which this software is used and send an email with the citation and, if possible, a PDF file of the paper to: staff@physiome.org.
    Or send a copy to:
    The National Simulation Resource, Director J. B. Bassingthwaighte, Department of Bioengineering, University of Washington, Seattle WA 98195-5061.

    [This page was last modified 02Nov16, 2:21 pm.]

    Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.